PEG and Pegylation
PEG, polyethylene glycol, traditionally refers to the one with low molecular weight (MW<20 kDa);
while its higher MW adduct is usually called as polyethylene oxide (PEO). PEG has several
chemical attributes that make it especially useful in various biological, pharmaceutical, and
chemical settings. For example:
Therefore, an important approach - pegylation, by coupling a PEG structure to a compound, finds
a great number of applications in pharmaceutical and biological fields. Pegylation technology is
now widely used to modify active pharmaceutical ingredients, peptides, proteins, antibody
components, oligonucleotides, and so forth, to lend some advantages as follows:
On a molecule of protein, peptide, or other components, there may exist multiple reactive sites
being attachable with PEG moiety. This would raise the concerns about the efficacy and
reproducibility of the pegylated product from lot to lot. To address this issue, we use some site-
specific pegylation methods, through which the pegylated products can be made with the
consistent efficacy. Furthermore, in the recent year, PEG2-based pegylation has been proven
more effective than the first generation of pegylation approach for many applications. We are
ready to collaborate with you in this field to boost the value of your promising products.
Please explore our PEG derivative products, or contact us to see how we can meet your needs for
PEG or pegylation products via our custom synthesis service.
PEG, polyethylene glycol, traditionally refers to the one with low molecular weight (MW<20 kDa);
while its higher MW adduct is usually called as polyethylene oxide (PEO). PEG has several
chemical attributes that make it especially useful in various biological, pharmaceutical, and
chemical settings. For example:
- Non-toxic / non-immunogenic – can be added to media and attached to surfaces and
conjugated to molecules without interfering with cellular functions or target
immunogenicities - Hydrophilic – attachment to proteins and other biomolecules decreases aggregation and
increases solubility - Highly flexible – provides for surface treatment or bioconjugation without steric hindrance
Therefore, an important approach - pegylation, by coupling a PEG structure to a compound, finds
a great number of applications in pharmaceutical and biological fields. Pegylation technology is
now widely used to modify active pharmaceutical ingredients, peptides, proteins, antibody
components, oligonucleotides, and so forth, to lend some advantages as follows:
- increased bioavailability
- increased blood circulation of the drug
- optimized pharmacokinetics
- decreased immunogenicity
- decreased frequency of administration
On a molecule of protein, peptide, or other components, there may exist multiple reactive sites
being attachable with PEG moiety. This would raise the concerns about the efficacy and
reproducibility of the pegylated product from lot to lot. To address this issue, we use some site-
specific pegylation methods, through which the pegylated products can be made with the
consistent efficacy. Furthermore, in the recent year, PEG2-based pegylation has been proven
more effective than the first generation of pegylation approach for many applications. We are
ready to collaborate with you in this field to boost the value of your promising products.
Please explore our PEG derivative products, or contact us to see how we can meet your needs for
PEG or pegylation products via our custom synthesis service.
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